Error-free and Mutagenic Processing of Topoisomerase I- provoked damage at genomic ribonucleotides

Thank you again for your patience and once more, apologies for the unusual delay with reviewing your submission on Top1 damage processing at genomic ribonucleotides. We have now finally received the complete set of reviewer comments, and I am happy to inform you that all three referees consider this work interesting and important and would be supportive of publication pending adequate addressing of a limited number of specific issues. I would therefore like to invite to prepare and submit a revised manuscript along the lines suggested by the referees. As you will see, the only potentially more serious caveat mentioned by referees 2 and 3 is the partially unclear connection of Top1 repair mechanisms to in vivo processes; and while I would not make extensions into that direction a prerequisite for further consideration at our journal, I feel that any results you may be able to add to address these concerns would be very helpful for increasing the significance of the study further.